Pharmacological Evaluation of Leaves Extract from Rivea Ornata Roxb.

From the study entitled "Pharmacological Evaluation of Leaves Extract from Rivea ornata Roxb., the following conclusion could be drawn. ❖ The present study has thus duly supported the traditional use of methanolic Extract of Rivea ornata Roxb. have scientifically proved the antihyperlipidemic, antidiabetic, analgesic, antipyretic and wound healing activity. ❖ Apart from the suggested actions listed in discussion part absence of acute toxicity and sub acute toxicity may also offer a new hope for safe treatment in future. ❖ Preliminary phytochemical study of methanolic extract of Rivea ornata Roxb. was found to contain Carbohydrates, Steroids, Alkaloids, Glycosides, Tannins, Phenolic compounds, Gums and mucilage are present. ❖ Presence of Alkaloids, Tannins and Glycosides in the methanolic extract of Rivea ornata Roxb. was observed in IR & HPTLC analysis. Though present in small quantities, it was found to produce considerable effects. ❖ The results of acute toxicity study indicate that the methanolic extract of Rivea ornata was non-toxic up to dose level of 2000mg/kg body weight in albino rats as per acute oral toxicity studies. 1/10th of the LD50 Dose is 200mg/kg is used for Pharmacological screening. ❖ The results of subacute toxicity study indicate that the methanolic extract of Rivea ornata was non-toxic in chronic administration. ❖ The methanolic extract of Rivea ornata at a dose of 200mg/kg exhibited significant hypolipidemic activity in Triton X 100 induced hyperlipidemic rats. This is showed by the reduction of serum lipid parameters such as triglycerides, total cholesterol, LDL, VLDL with an increase in HDL concentration in the group treated with 200mg/kg of methanolic Extract of Rivea ornata. ❖ The methanolic extract of Rivea ornata at a dose of 200mg/kg showed significant antidiabetic activity in Alloxan induced hyperglycemic rats. This is showed by the reduction of blood glucose level in the group treated with 200mg/kg of methanolic extract of Rivea ornata. ❖ The methanolic extract of Rivea ornata was subjected to the Tail immersion and hot plate method Analgesic test, showed a significant analgesic effect. ❖ The methanolic extract of Rivea ornata was subjected to the Antipyretic activity against Brewer’s yeast induced hyperpyrexia showed a significant reduce in body temperature of the animals treated with 200mg/kg of methanolic extract of Rivea ornata. ❖ The methanolic extract of Rivea ornata was subjected to the wound healing activity, showed a significant wound healing effect on excision wound in rats. ❖ In future, further investigation might provide an insight to identify the functional groups in the methanolic extract of Rivea ornata responsible for the antihyperlipidemic, antidiabetic, analgesic, antipyretic and wound healing activity and to elucidate the exact mechanism of action, which is responsible for the observed significant activity with low toxicity and better therapeutic index